Iodine-125 Radioiodination Services

Iodination of peptides and proteins, as well as small molecules, results in materials with high specific activity.

Generally, Iodine-125 is incorporated into available tyrosine residues under oxidative conditions. Various compatible oxidative reagents of differing strengths exist (e.g. Chloramine-T, Iodogen, Lactoperoxidase) and can be chosen to accommodate sensitive molecules.

Additionally, for compounds lacking a tyrosine or histidine or are simply incompatible with other iodination techniques, labeling of free amines can occur through the use of [125I]-Bolton-Hunter Reagent.

Due to the wide variety of compounds amenable to 125I labeling and a number of variables involved to achieve desired specifications, please contact us to discuss your projectís needs.